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CD4 peptide-protein conjugates, but not recombinant human CD4, bind to recombinant gp120 from the human immunodeficiency virus in the presence of serum from AIDS patients.在艾滋病患者血清存在的情况下，CD4肽-蛋白偶联物而非重组人CD4，能与人免疫缺陷病毒的重组gp120结合。
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Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.对CD4的V1区域中参与与人免疫缺陷病毒包膜糖蛋白gp120及II类主要组织相容性复合体分子相互作用的残基进行鉴定和结构分析。
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Interference of coronavirus infection by expression of immunoglobulin G (IgG) or IgA virus-neutralizing antibodies.通过表达免疫球蛋白G（IgG）或IgA病毒中和抗体对冠状病毒感染的干扰。
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Intracellular interference of tick-borne flavivirus infection by using a single-chain antibody fragment delivered by recombinant Sindbis virus.利用重组辛德毕斯病毒递送的单链抗体片段对蜱传黄病毒感染进行细胞内干扰。
J Virol. 1995 Feb;69(2):1044-9. doi: 10.1128/JVI.69.2.1044-1049.1995.
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Inhibition of HIV-1 Tat-mediated LTR transactivation and HIV-1 infection by anti-Tat single chain intrabodies.抗Tat单链抗体对HIV-1 Tat介导的LTR反式激活及HIV-1感染的抑制作用
EMBO J. 1995 Apr 3;14(7):1542-51. doi: 10.1002/j.1460-2075.1995.tb07140.x.

本文引用的文献

1
Design, intracellular expression, and activity of a human anti-human immunodeficiency virus type 1 gp120 single-chain antibody.人抗人免疫缺陷病毒1型gp120单链抗体的设计、细胞内表达及活性
Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7889-93. doi: 10.1073/pnas.90.16.7889.
2
Single-chain antigen-binding proteins.单链抗原结合蛋白
Science. 1988 Oct 21;242(4877):423-6. doi: 10.1126/science.3140379.
3
A new means of inducibly inactivating a cellular protein.一种诱导细胞蛋白失活的新方法。
Mol Cell Biol. 1988 Jun;8(6):2638-46. doi: 10.1128/mcb.8.6.2638-2646.1988.
4
Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.抗体结合位点的蛋白质工程：在大肠杆菌中产生的抗地高辛单链Fv类似物中恢复比活性。
Proc Natl Acad Sci U S A. 1988 Aug;85(16):5879-83. doi: 10.1073/pnas.85.16.5879.
5
Molecular tools for inactivating a yeast enzyme in vivo.用于在体内使酵母酶失活的分子工具。
Mol Cell Biol. 1988 Jun;8(6):2647-50. doi: 10.1128/mcb.8.6.2647-2650.1988.
6
Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein.
Nature. 1985;314(6012):639-42. doi: 10.1038/314639a0.
7
Production of antibodies in transgenic plants.转基因植物中抗体的产生。
Nature. 1989 Nov 2;342(6245):76-8. doi: 10.1038/342076a0.
8
Expression and targeting of intracellular antibodies in mammalian cells.细胞内抗体在哺乳动物细胞中的表达与靶向作用。
EMBO J. 1990 Jan;9(1):101-8. doi: 10.1002/j.1460-2075.1990.tb08085.x.
9
Synthesis and self-assembly of a functional monoclonal antibody in transgenic Nicotiana tabacum.功能性单克隆抗体在转基因烟草中的合成与自组装。
Plant Mol Biol. 1990 Aug;15(2):281-93. doi: 10.1007/BF00036914.
10
Yeast expression of a catalytic antibody with chorismate mutase activity.具有分支酸变位酶活性的催化抗体的酵母表达。
J Biol Chem. 1991 Jun 25;266(18):11901-8.

A new use for intracellular antibody expression: inactivation of human immunodeficiency virus type 1.

作者信息

Carlson J R

机构信息

Department of Biology, Yale University, New Haven, CT 06511-8112.

出版信息

Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7427-8. doi: 10.1073/pnas.90.16.7427.

DOI:10.1073/pnas.90.16.7427
PMID:8356037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC47153/
Abstract
摘要