藜芦碱和可卡因对突触体多巴胺释放动力学的影响。
Effects of veratridine and cocaine on the kinetics of synaptosomal dopamine release.
作者信息
Wheeler D D, Chapman B M, Ondo J G
机构信息
Department of Physiology, Medical University of South Carolina, Charleston 29425.
出版信息
Pharmacology. 1993 Aug;47(2):117-25. doi: 10.1159/000139086.
Following preloading of striatal synaptosomes with 3H-dopamine (DA), the kinetics of release have been followed for a 60-min incubation period. DA appears to be totally releasable under both depolarizing (veratridine) and nondepolarizing conditions. Cocaine has no significant effect on release under either condition. Release is consistent with a model consisting of two parallel, linear compartments (when plotted as a log function). It is proposed that the slower compartment might represent the operation of the DA transporter, while the faster compartment might represent vesicular release.
在用3H-多巴胺（DA）预加载纹状体突触体后，在60分钟的孵育期内跟踪了释放动力学。DA在去极化（藜芦碱）和非去极化条件下似乎都能完全释放。在任何一种条件下，可卡因对释放均无显著影响。释放与由两个平行的线性区室组成的模型一致（以对数函数绘制时）。有人提出，较慢的区室可能代表DA转运体的运作，而较快的区室可能代表囊泡释放。
Zotero 插件