Blanford A T, Murphy B E
Am J Obstet Gynecol. 1977 Feb 1;127(3):264-7. doi: 10.1016/0002-9378(77)90466-5.
Many of the factors influencing the pharmacologic action of corticosteroids on the maternal-placental-fetal unit remains obscure. To clarify the effect of the placenta on corticoid transfer, tritiated steroids were incubated in saline for 2 hours with minces of midgestational or term placental tissue. The media were extracted and chromatographed on Sephadex-LH-20. Large peaks corresponding to the inactive 11-keto metabolites were observed for cortisol (67 per cent) and prednisolone (51 per cent) while conversion of dexamethasone (1.8 per cent) and betamethasone (7.1 per cent) was low or negligible.
许多影响皮质类固醇对母-胎-胎盘单位药理作用的因素仍不清楚。为了阐明胎盘对皮质类固醇转运的影响，将氚标记的类固醇与妊娠中期或足月胎盘组织碎片在盐水中孵育2小时。提取培养基并在Sephadex-LH-20上进行色谱分析。观察到皮质醇（67%）和泼尼松龙（51%）有与无活性11-酮代谢物相对应的大峰，而地塞米松（1.8%）和倍他米松（7.1%）的转化率很低或可忽略不计。
