Song Y P, Xu S T, Ou Y Q
Neurophysiology Research Laboratory, South China Normal University, Guangzhou.
Sheng Li Xue Bao. 1993 Apr;45(2):111-6.
In the present study, the role of NE in learning-dependent long-term potentiation (LdLTP) was investigated by examining the effects of 6-hydroxydopamine (6-OHDA) lesion made in the bilateral dorsal noradrenergic bundle on the changes of synaptic efficacy in dentate gyrus (DG) and related conditioned response during drinking conditioning. Bilateral injection of 6-OHDA (12 micrograms/4 microliters) into the dorsal noradrenergic bundle caused a continuous decrease of the amplitude of population spike (PS) reaching a value of 50 +/- 6.3% and 28 +/- 6.4% respectively at the 6th and the 12th day after injection of the drug. During this period of 7 days, the LdLTP could not be produced in spite of 20 trainings per day for a total of 140 trials, and the conditioned drinking response could not be established. The above results indicate that normal levels of norepinephrine in the hippocampus are necessary to the establishment of LdLTP in the DG and suggest that the development of LdLTP in the DG may be modulated by the nucleus locus ceruleus via the dorsal noradrenergic bundle.
在本研究中，通过检测双侧背侧去甲肾上腺素能束中6-羟基多巴胺（6-OHDA）损伤对饮水条件反射期间齿状回（DG）突触效能变化及相关条件反应的影响，研究了去甲肾上腺素（NE）在学习依赖性长时程增强（LdLTP）中的作用。向双侧背侧去甲肾上腺素能束注射6-OHDA（12微克/4微升）导致群体峰电位（PS）幅度持续下降，在注射药物后的第6天和第12天分别降至50±6.3%和28±6.4%。在这7天期间，尽管每天进行20次训练，共140次试验，但仍无法产生LdLTP，且无法建立条件性饮水反应。上述结果表明，海马中去甲肾上腺素的正常水平对于DG中LdLTP的建立是必要的，并提示DG中LdLTP的发展可能受蓝斑核通过背侧去甲肾上腺素能束的调节。
