Zhang C C, Zhou Y S, Zhang Q H
Department of Physiology, Third Military Medical College, Chongqing.
Sheng Li Xue Bao. 1992 Oct;44(5):442-7.
The role of hippocampal noradrenergic and dopaminergic transmission in the acquisition and retention of active conditioned avoidance behavior was investigated in rats by injection of 6-hydroxydopamine (6-OHDA) into dorsal hippocampus. The main results are as follows: (1) After injection of 6-OHDA the contents of dopamine, particularly norepinephrine (P < 0.01) in the hippocampus was decreased significantly. (2) The acquisition of conditioned avoidance behavior was markedly impaired. (3) The facilitating effect of AVP on retention of active conditioned avoidance behavior could be eliminated by prior injection of 6-OHDA bilaterally into hippocampus.
通过向大鼠背侧海马注射6-羟基多巴胺（6-OHDA），研究了海马去甲肾上腺素能和多巴胺能传递在主动条件性回避行为的获得和保持中的作用。主要结果如下：（1）注射6-OHDA后，海马中多巴胺，尤其是去甲肾上腺素的含量显著降低（P < 0.01）。（2）条件性回避行为的获得明显受损。（3）预先双侧海马注射6-OHDA可消除精氨酸加压素对主动条件性回避行为保持的促进作用。
