Lian Q L, Ni G T, Cheng T, Tao H Y, Hang R C, Qian B R
Department of Diving Physiology, Faculty of Naval Medicine, Second Military Medical University, Shanghai.
Sheng Li Xue Bao. 1993 Apr;45(2):182-5.
The purpose of this study is to investigate the changes of Leu-Enkephalin (L-Enk) content in striatum and hypothalamus of rats during hyperbaric (HBO) oxygen exposure. Thirty-two male rats in the experiment were randomly divided into four groups: normobaric air group, normoxic hyperbaric nitrox group, nonconvulsion HBO group and convulsion HBO group. L-Enk content in striatum and hypothalamus was determined by radioimmunoassay. The results show that L-Enk content in the striatum and hypothalamus of rats exposed to hyperbaric oxygen environment were markedly higher than that of rats exposed to normobaric air and normoxic hyperbaric nitrox. The experimental results suggest that the elevation of L-Enk content in striatum and hypothalamus shows a positive relationship with the HBO exposure duration of animals and that there was no marked relationship with normoxic hyperbaric nitrox environment and compression-decompression method.
本研究旨在探讨高压氧（HBO）暴露期间大鼠纹状体和下丘脑亮氨酸脑啡肽（L-Enk）含量的变化。实验中的32只雄性大鼠被随机分为四组：常压空气组、常氧高压氮氧混合气组、非惊厥性HBO组和惊厥性HBO组。采用放射免疫分析法测定纹状体和下丘脑的L-Enk含量。结果显示，暴露于高压氧环境的大鼠纹状体和下丘脑L-Enk含量明显高于暴露于常压空气和常氧高压氮氧混合气的大鼠。实验结果表明，纹状体和下丘脑L-Enk含量的升高与动物的HBO暴露时间呈正相关，与常氧高压氮氧混合气环境及加压-减压方法无明显关系。
