用丙咪嗪或阿米替林长期治疗期间大鼠脑内亮氨酸脑啡肽含量

Leu-enkephalin content in rat brain during prolonged treatment with imipramine or amitriptyline.

作者信息

Obuchowicz E, Herman Z S, Felińska W

机构信息

Department of Clinical Pharmacology, Silesian Medical Academy, Katowice, Poland.

出版信息

Pol J Pharmacol Pharm. 1988 Nov-Dec;40(6):635-41.

PMID:3269533

Abstract

The influence of imipramine (IMI) or amitriptyline (AMI) on the level of immunoreactive leu-enkephalin (ir-LENK) in the striatum and hypothalamus was studied in rats. Each drug was given by drinking water once or over periods of 1, 3, 4 and 6 months. The ir-LENK in brain perfusates was measured after 3 or 9 month treatment with IMI. The results obtained indicate that during prolonged administration of IMI the central enkephalinergic system is dynamically changed. We have observed that chronic (but not acute) administration of IMI induced different effects on LENK level in the examined structures than changes caused by treatment with AMI.

摘要

研究了丙咪嗪（IMI）或阿米替林（AMI）对大鼠纹状体和下丘脑免疫反应性亮氨酸脑啡肽（ir-LENK）水平的影响。每种药物通过饮水给药一次或持续1、3、4和6个月。在用IMI治疗3或9个月后，测量脑灌注液中的ir-LENK。所得结果表明，在长期给予IMI期间，中枢脑啡肽能系统发生动态变化。我们观察到，IMI的慢性（而非急性）给药对所检查结构中LENK水平的影响与AMI治疗引起的变化不同。