Benton L D, Khan M, Greco R S
Department of Surgery, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903.
Surg Gynecol Obstet. 1993 Sep;177(3):311-27.
Integrins and adhesion molecules are a group of closely related glycoproteins expressed by a wide variety of cells. In vitro experiments have shown these families of cell surface receptors to be essential to the interactions between the cytoskeleton and the extracellular matrix. Although the designations of families of integrins and adhesion molecules is complex, this review attempts to present an organization in which the result is to provide surgeons with an understanding of their structure and function. This is particularly important because integrins and adhesion molecules have a critical role in such diverse processes as embryogenesis, inflammation, wound healing, thrombosis, transplantation and oncogenic transformation. It is, therefore, highly probable that they will be critical to future advances in surgical research and ultimately in surgical practice. It should be remembered that this area of investigation is so dynamic that the interval involved in publication of this article will in itself be characterized by a plethora of publications in the basic science and surgical literature, which warrants careful attention.
整合素和黏附分子是一类由多种细胞表达的密切相关的糖蛋白。体外实验表明，这些细胞表面受体家族对于细胞骨架与细胞外基质之间的相互作用至关重要。尽管整合素和黏附分子家族的命名很复杂，但本综述试图呈现一种架构，其结果是让外科医生了解它们的结构和功能。这一点尤为重要，因为整合素和黏附分子在胚胎发生、炎症、伤口愈合、血栓形成、移植和致癌转化等多种过程中发挥着关键作用。因此，它们极有可能对未来外科研究的进展乃至最终的外科实践至关重要。应该记住，这个研究领域非常活跃，以至于在本文发表期间，基础科学和外科文献本身就会涌现大量的出版物，这值得密切关注。
