Kaufmann R, Weber L, Klein C E
Dermatologische Klinik, Universität Ulm.
Hautarzt. 1990 May;41(5):256-61.
The integrins are a newly defined family of cell surface receptors. They are involved in the adhesion of cells to the extracellular matrix and to other cells. Integrins and their ligands may be required for complex physiological and pathophysiological events, such as epidermal differentiation, inflammation, immune response, wound healing or tumour progression. Some of the integrin receptor molecules are expressed in a distinct distribution pattern within the skin. Three of them are found selectively in the basal layer of the epidermis, suggesting an important role in establishment of the functional integrity of the dermo-epidermal junction. In the present paper we summarize the available data on the structure and function of integrins and report on the expression of these molecules within the skin and their regulation in cell cultures.
整合素是一类新定义的细胞表面受体家族。它们参与细胞与细胞外基质以及其他细胞的黏附。整合素及其配体可能参与复杂的生理和病理生理过程，如表皮分化、炎症、免疫反应、伤口愈合或肿瘤进展。一些整合素受体分子在皮肤内以独特的分布模式表达。其中三种在表皮基底层中选择性表达，这表明它们在建立真皮 - 表皮连接的功能完整性方面具有重要作用。在本文中，我们总结了关于整合素结构和功能的现有数据，并报告了这些分子在皮肤内的表达及其在细胞培养中的调控情况。
