DePetrillo P B, Kurl R N
Program in Clinical Pharmacology, Brown University School of Medicine, Rhode Island Hospital (SWP-406), Providence 02903.
Toxicol Lett. 1993 Jul;69(1):31-6. doi: 10.1016/0378-4274(93)90142-k.
Exposure of immature thymocytes to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (10 nM) transiently increased detergent extractable protein kinase C (PKC) activity. The increase was apparent at 7.5 min after exposure of cells to TCDD. At later time points, PKC activity returned to control values. Addition of TCDD to cytosol significantly increased phospholipid-stimulated PKC activity. Thus, stimulation of PKC activity may be one of the early events affected by TCDD.
将未成熟胸腺细胞暴露于2,3,7,8-四氯二苯并对二恶英（TCDD）（10 nM）中会短暂增加去污剂可提取的蛋白激酶C（PKC）活性。细胞暴露于TCDD后7.5分钟时，这种增加很明显。在随后的时间点，PKC活性恢复到对照值。向细胞溶质中添加TCDD可显著增加磷脂刺激的PKC活性。因此，PKC活性的刺激可能是受TCDD影响的早期事件之一。
