Human placental cholesterol side-chain cleavage: enzymatic synthesis of (22R)-20 alpha,22-dihydroxycholesterol.
作者信息
Tuckey R C, Cameron K J
机构信息
Department of Biochemistry, University of Western Australia, Nedlands.
出版信息
Steroids. 1993 May;58(5):230-3. doi: 10.1016/0039-128x(93)90024-h.
PMID:8356576
Abstract
(22R)-20 alpha,22-Dihydroxycholesterol is the second intermediate in the conversion of cholesterol to pregnenolone by cytochrome P450scc in steroidogenic tissues. We report a rapid method for the enzymatic synthesis of (22R)-20 alpha,22-dihydroxycholesterol from (22R)-22-hydroxycholesterol using mitochondria from the human placenta.
摘要
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