Erez E, Aravot D, Erman A, Sharoni E, van Oyk D J, Raanani E, Abramov D, Sulkes J, Vidne B A
Department of Cardiothoracic Surgery, Rabin Medical Center (Beilinson Campus), Petch Tikva, Israel.
J Heart Lung Transplant. 1998 May;17(5):538-41.
Serum beta2-microglobulin (beta2m) levels were measured to evaluate the state of immunoactivation in stable heart transplant recipients. Serum beta2m and renal function of 29 heart transplant recipients were compared with 16 control subjects, who were age and sex matched, and 11 patients with chronic kidney failure. Serum creatinine and 24-hour urine collection for albuminuria were used as markers of renal impairment. Heart transplant recipients with normal renal function (n = 7) had significantly elevated beta2m levels compared with control subjects: 2.6 +/- 0.9 vs 1.66 +/- 0.32 microg/ml, p < or = 0.05. Heart transplant recipients with impaired renal function (n = 22) had significantly elevated beta2m compared with the chronic kidney failure group: 4.42 +/- 1.3 vs 3.49 +/- 0.66 microg/ml (p < or = 0.05); although there was no significant difference in serum creatinine levels. Albuminuria excretion was significantly elevated in the chronic kidney failure group compared with the heart transplant recipients with impaired renal function (p < or = 0.05). Elevated serum beta2m in heart transplant recipients suggests increased beta2m production, reflecting increased immunoactivation. This observation could be useful in monitoring long-term immunosuppressive therapy.
检测血清β2-微球蛋白（β2m）水平，以评估稳定期心脏移植受者的免疫激活状态。将29例心脏移植受者的血清β2m水平及肾功能与16例年龄和性别匹配的对照受试者以及11例慢性肾衰竭患者进行比较。血清肌酐和24小时尿白蛋白定量用作肾功能损害的标志物。肾功能正常的心脏移植受者（n = 7）与对照受试者相比，β2m水平显著升高：分别为2.6±0.9与1.66±0.32μg/ml，p≤0.05。肾功能受损的心脏移植受者（n = 22）与慢性肾衰竭组相比，β2m显著升高：分别为4.42±1.3与3.49±0.66μg/ml（p≤0.05）；尽管血清肌酐水平无显著差异。与肾功能受损的心脏移植受者相比，慢性肾衰竭组的白蛋白尿排泄显著升高（p≤0.05）。心脏移植受者血清β2m升高提示β2m产生增加，反映免疫激活增强。该观察结果可能有助于监测长期免疫抑制治疗。
