Carpenter R J, Angel M F, Amiss L R, Masterson T M, Morgan R F
Department of Surgery, University of Rochester School of Medicine, NY.
Arch Otolaryngol Head Neck Surg. 1993 Sep;119(9):1015-7. doi: 10.1001/archotol.1993.01880210105014.
The effect of verapamil, a calcium channel blocker, on the survival of skin flaps subjected to primary venous obstruction was studied. Skin flaps 9 x 4 cm, which are axial patterns with random extension, were elevated in Sprague-Dawley rats. A microvascular clamp was placed on the vein alone for 8 hours. Group 1 received verapamil (0.3 mg/kg) before flap elevation and before clamp release; group 2 received saline on the same schedule. Group 3 received verapamil (0.3 mg/kg) as above, plus every 8 hours for 5 days postoperatively. Group 4 received saline on the same schedule. There was no difference in survival between groups 1 and 2. Group 3 had 100% improvement in the flap survival compared with group 4 (78% vs 37%). Verapamil, if administered for the duration of the experiment, significantly increased flap survival.
研究了钙通道阻滞剂维拉帕米对原发性静脉阻塞皮瓣存活的影响。在Sprague-Dawley大鼠中掀起9×4cm的轴型随机延伸皮瓣。用微血管夹单独夹闭静脉8小时。第1组在皮瓣掀起前和夹闭松开前给予维拉帕米（0.3mg/kg）；第2组按相同时间表给予生理盐水。第3组按上述方法给予维拉帕米（0.3mg/kg），并在术后每8小时给药一次，持续5天。第4组按相同时间表给予生理盐水。第1组和第2组的皮瓣存活情况无差异。与第4组相比，第3组皮瓣存活率提高了100%（分别为78%和37%）。如果在实验期间给予维拉帕米，可显著提高皮瓣存活率。
