Baldo Sierra C, Núñez Batalla F, Domínguez O, Suárez Nieto C, Alvarez Alvarez I, Fresno Forcelledo M, López Larrea C
Servicio de Otorrinolaringología, Hospital Central de Asturias, Oviedo.
Acta Otorrinolaringol Esp. 1993 May-Jun;44(3):165-8.
Ras genes can acquire transforming properties by qualitative and quantitative mechanisms. The mutated products of ras oncogenes (p21 protein) exhibit a decreased ability to hydrolyze GTP that lead to the stabilization of ras proteins in their active state and cause a continuous flow of signal transduction which may result in malignant transformation. These biochemical aberrant properties can also be achieved by an increased expression of the normal p21 protein. In this work we have analyzed the presence of ras gene mutations and the overexpression of the oncogene product p21 in the same series of squamous cell carcinoma of pharynx and larynx. Of 13 cases studied we have detected mutations in seven cases and in nine we have observed overexpression of the p21 protein. There is no correlation between ras mutations and overexpression of the p21 protein.
Ras基因可通过定性和定量机制获得转化特性。ras癌基因的突变产物（p21蛋白）水解GTP的能力下降，这导致ras蛋白稳定在其活性状态，并引起信号转导的持续流动，这可能导致恶性转化。这些生化异常特性也可通过正常p21蛋白表达增加来实现。在这项工作中，我们分析了同一组咽喉鳞状细胞癌中ras基因突变的存在情况以及癌基因产物p21的过表达情况。在所研究的13例病例中，我们在7例中检测到突变，在9例中观察到p21蛋白过表达。ras突变与p21蛋白过表达之间无相关性。
