通过钙刺激释放血管活性肠肽。

Release of VIP by calcium stimulation.

作者信息

Ebeid A M, Murray P, Soeters P B, Fischer J E

出版信息

Am J Surg. 1977 Jan;133(1):140-4. doi: 10.1016/0002-9610(77)90208-2.

Abstract

Calcium has been shown to be a reliable releaser of VIP, as has been observed with most peptide hormones. VIP is released throughthe gastrointestinal tract. The challenge of VIP release by calcium could reveal different "potentials" in the production of the hormone, that are not appreciated in the basal state. Calcium stimulation thus showed a slightly greater level of VIP release from the pancreaticoduodenal vein than from the portal radicals. But although the significance of this finding remains to be defined, calcium release could have a clinical applicability in the challenge of equivocal VIPomas.

摘要

正如大多数肽类激素所观察到的那样，钙已被证明是血管活性肠肽（VIP）的可靠释放剂。VIP通过胃肠道释放。钙对VIP释放的刺激可能揭示该激素产生过程中的不同“潜力”，而这些在基础状态下未被认识到。因此，钙刺激显示，胰腺十二指肠静脉中VIP的释放水平略高于门静脉分支。但是，尽管这一发现的意义尚待确定，但钙释放可能在诊断不明确的VIP瘤方面具有临床应用价值。