Artacho-Pérula E, Roldán-Villalobos R
Department of Morphological Sciences (Section of Histology), School of Medicine, University of Córdoba, Spain.
Histol Histopathol. 1993 Jul;8(3):443-8.
The individual nuclear size was studied in three groups of endometrial samples (simple hyperplasia -SH-, atypical hyperplasia -AH-, and well-differentiated adenocarcinoma -WDA-). The application of recent semiquantitative systems in combination with stereological methods permits a simple, quick and unbiased estimation of the volume-weighted mean nuclear volume vv(nucl). We have found an increase in the vv(nucl) from SH to AH to WDA. There are significant differences between the mean of the three groups (p < 0.01). The variance associated with estimates of vv(nucl) is mainly provided by differences among lesions; i.e. patients. This capacity for discriminating may be associated with gland and lumen endometrial quantification to improve the correct diagnosis of endometrial samples.
对三组子宫内膜样本（单纯性增生-SH-、非典型增生-AH-和高分化腺癌-WDA-）的单个细胞核大小进行了研究。将近期的半定量系统与体视学方法相结合，能够简单、快速且无偏地估计体积加权平均核体积vv(nucl)。我们发现从SH到AH再到WDA，vv(nucl)呈增加趋势。三组的平均值之间存在显著差异（p < 0.01）。与vv(nucl)估计值相关的方差主要由病变（即患者）之间的差异所致。这种鉴别能力可能与子宫内膜腺体和管腔的量化有关，以改善子宫内膜样本的正确诊断。
