Llovera M, López-Soriano F J, Argilés J M
Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain.
Biochem Mol Biol Int. 1993 May;30(1):29-36.
Chronic TNF treatment for 8 days resulted in an increased protein turnover in most of the tissues studied. The increased turnover could be observed in both the synthetic and degradation fractional constants; however, in the majority of the tissues (muscle, diaphragm, heart, kidneys, lungs and brown adipose) the increase in Kd was higher than that of Ks resulting thus in a reduced protein accumulation (Ka). In contrast, chronic TNF treatment resulted in an increased brain protein accumulation. The data presented suggest that the cytokine could be involved in tissue wasting in pathological states such as sepsis and malignancy.
8天的慢性肿瘤坏死因子（TNF）治疗导致大部分研究组织中的蛋白质周转率增加。在合成和降解分数常数中均能观察到周转率的增加；然而，在大多数组织（肌肉、膈肌、心脏、肾脏、肺和棕色脂肪）中，降解常数（Kd）的增加高于合成常数（Ks），从而导致蛋白质积累（Ka）减少。相反，慢性TNF治疗导致脑蛋白质积累增加。所呈现的数据表明，这种细胞因子可能参与脓毒症和恶性肿瘤等病理状态下的组织消耗。
