Wroblewski B, Glenn M B, Cornblatt R, Joseph A B, Suduikis S
Greenery Rehabilitation Center, Boston, MA 02135.
Brain Inj. 1993 Jul-Aug;7(4):353-62. doi: 10.3109/02699059309034962.
The results of a series of eight individual case reports in which protriptyline, an activating tricyclic antidepressant, was used as a 'stimulant' medication are presented. For some patients with head injury, traditional stimulants, such as methylphenidate, or dopaminergic stimulants, such as levodopa-carbidopa, amantadine, or bromocriptine, may be partially or totally ineffective or not tolerated. Protriptyline can be a very effective alternative and, for some patients, may be the most effective stimulant tried. In low to moderate doses, protriptyline should be considered for trials as an activating/stimulant medication in patients with head injury.
本文呈现了一系列八例个体病例报告的结果，其中使用了一种具有激活作用的三环类抗抑郁药普罗替林作为“兴奋”药物。对于一些头部受伤的患者，传统的兴奋剂，如哌甲酯，或多巴胺能兴奋剂，如左旋多巴-卡比多巴、金刚烷胺或溴隐亭，可能部分或完全无效，或无法耐受。普罗替林可能是一种非常有效的替代药物，对一些患者来说，可能是尝试过的最有效的兴奋剂。对于头部受伤的患者，在低至中等剂量下，应考虑将普罗替林作为一种激活/兴奋药物进行试验。
