Pietrini P, Azari N P, Grady C L, Salerno J A, Gonzales-Aviles A, Heston L L, Pettigrew K D, Horwitz B, Haxby J V, Schapiro M B
Laboratory of Neurosciences, National Institute on Aging, NIH, Bethesda, MD 20892.
Dementia. 1993 Mar-Apr;4(2):94-101. doi: 10.1159/000107349.
A pattern of reduced cerebral metabolic rate for glucose (rCMRglc) has been shown by positron emission tomography (PET) in patients with dementia of the Alzheimer type. To verify if a similar rCMRglc pattern is present in subjects 'at risk' for Alzheimer's disease (AD), we used high-resolution PET to longitudinally study a subject with isolated memory impairment and a family history for autosomal dominant AD. Initial rCMRglc data did not reveal any consistent abnormality as compared to a group of sex- and age-matched healthy controls. However, 1 year later, a follow-up evaluation did reveal reduced parietal rCMRglc values coinciding with a worsening of cognitive impairment, which suggested that standard analyses of resting rCMRglc data may not be useful in the early diagnosis of AD. In contrast, when a previously determined discriminant function for distinguishing controls from AD patients was applied, the subject was correctly identified as an AD patient on both PET scans.
正电子发射断层扫描（PET）已显示，阿尔茨海默型痴呆患者存在葡萄糖脑代谢率降低（rCMRglc）的模式。为了验证在阿尔茨海默病（AD）“风险”受试者中是否存在类似的rCMRglc模式，我们使用高分辨率PET对一名患有孤立性记忆障碍且有常染色体显性AD家族史的受试者进行了纵向研究。与一组性别和年龄匹配的健康对照相比，初始rCMRglc数据未显示任何一致的异常。然而，1年后的随访评估确实显示，顶叶rCMRglc值降低，同时认知障碍加重，这表明静息rCMRglc数据的标准分析可能对AD的早期诊断无用。相比之下，当应用先前确定的区分对照与AD患者的判别函数时，该受试者在两次PET扫描中均被正确识别为AD患者。
