Omara F O, Blakley B R
Department of Veterinary Physiological Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon.
Can J Vet Res. 1993 Jul;57(3):209-11.
Weanling male CD-1 mice were fed low iron (7 ppm), control (120 ppm) and iron loaded diets (3000 or 5000 ppm) for 19 weeks. After seven weeks, the mice received 1.5 mg urethan/g ip, and tumor development was evaluated 12 weeks later. The low iron diet increased the incidence of lung adenomas by 86%. The iron loaded diets did not influence adenoma development. Tumor size was unaffected by iron status (p = 0.297). These results indicate that low iron body status promotes tumor development and are inconsistent with the hypothesis that excess iron promotes cancer growth and that low iron protects against tumor growth.
将断乳雄性CD-1小鼠分别喂食低铁（7 ppm）、对照（120 ppm）和高铁饮食（3000或5000 ppm）19周。7周后，小鼠腹腔注射1.5 mg氨基甲酸乙酯/克体重，12周后评估肿瘤发生情况。低铁饮食使肺腺瘤发生率增加了86%。高铁饮食对腺瘤发生没有影响。肿瘤大小不受铁状态的影响（p = 0.297）。这些结果表明，低铁身体状态促进肿瘤发生，这与过量铁促进癌症生长以及低铁预防肿瘤生长的假设不一致。
