新大陆利什曼病：当前概念及对未来研究的启示
Leishmaniases of the New World: current concepts and implications for future research.
作者信息
Grimaldi G, Tesh R B
机构信息
Department of Immunology, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
出版信息
Clin Microbiol Rev. 1993 Jul;6(3):230-50. doi: 10.1128/CMR.6.3.230.
Abstract
Recent epidemiologic studies indicate that leishmaniasis in the Americas is far more abundant and of greater public health importance than was previously recognized. The disease in the New World is caused by a number of different parasite species that are capable of producing a wide variety of clinical manifestations. The outcome of leishmanial infection in humans is largely dependent on the immune responsiveness of the host and the virulence of the infecting parasite strain. This article reviews current concepts of the clinical forms, immunology, pathology, laboratory diagnosis, and treatment of the disease as well as aspects of its epidemiology and control. Recommendations for future research on the disease and its control are made.
摘要
近期的流行病学研究表明，美洲的利什曼病比以往认为的更为普遍，且对公共卫生的重要性更大。新世界的这种疾病由多种不同的寄生虫物种引起，这些物种能够产生多种多样的临床表现。人类利什曼原虫感染的结果在很大程度上取决于宿主的免疫反应性和感染寄生虫菌株的毒力。本文综述了该疾病的临床类型、免疫学、病理学、实验室诊断、治疗以及流行病学和控制方面的当前概念。并对该疾病及其控制的未来研究提出了建议。
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Leishmanicidal activity of amino acid and peptide esters.氨基酸和肽酯的杀利什曼原虫活性。
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