Farney R J, Morris A H, Armstrong J D, Hammer S
Am Rev Respir Dis. 1977 Jan;115(1):135-45. doi: 10.1164/arrd.1977.115.1.135.
Pulmonary reactions may follow therapy with nitrogen mustard, vincristine, procarbazine, and prednisone. Two patients with Hodgkin's disease are described who were treated with nitrogen mustard, vincristine, procarbazine, and prednisone and developed diffuse lung disease. Their disease processes were evaluated with serial pulmonary function studies, chest radiography, and open lung biopsy. Hypersensitivity reactions appeared to be responsible, and treatment with corticosteroids was successful. Procarbazine may have been the responsible agent.
使用氮芥、长春新碱、丙卡巴肼和泼尼松治疗后可能会出现肺部反应。本文描述了两名患有霍奇金淋巴瘤的患者，他们接受了氮芥、长春新碱、丙卡巴肼和泼尼松治疗，并出现了弥漫性肺部疾病。通过系列肺功能研究、胸部X光检查和开胸肺活检对他们的病情进行了评估。超敏反应似乎是病因，使用皮质类固醇治疗取得了成功。丙卡巴肼可能是致病因素。
