Mennuti M T, Shepard T H, Mellman W J
Obstet Gynecol. 1975 Aug;46(2):194-6.
A case of human fetal renal maldevelopment following the administration of nitrogen mustard, vincristine, procarbazine, and prednisone in early pregnancy for therapy of Hodgkin's disease is reported. While these agents have been shown to be teratogenic in animal experiments, adverse fetal effects following their use during early human pregnancy have not been described. In spite of this previous experience, it has generally been recommended that these agents be withheld during the first trimester of pregnancy because of their presumed teratogenic potential. This case would seem to reinforce this recommendation.
报告了一例在妊娠早期因治疗霍奇金病而使用氮芥、长春新碱、丙卡巴肼和泼尼松后出现人类胎儿肾脏发育异常的病例。虽然这些药物在动物实验中已被证明具有致畸性，但在人类妊娠早期使用后对胎儿的不良影响尚未见报道。尽管有过这样的经验，但由于其潜在的致畸可能性，一般仍建议在妊娠头三个月停用这些药物。该病例似乎进一步支持了这一建议。
