Niewoehner D E, Kleinerman J
Am Rev Respir Dis. 1977 Jan;115(1):15-21. doi: 10.1164/arrd.1977.115.1.15.
The length of elastic fibers and the distribution of fiber diameters was determined by morphometry in the parenchyma of human lungs. Studies were done on 33 lungs from male subjects 1 to 85 years of age, including 9 lungs with mild emphysema. These studies suggest that the total length of elastic fibers is present early in life, possible by 10 years of age, and thereafter remains constant. Average fiber diameter increases between infancy and adulthood but probably does not change further beyond the third decade of life. No significant differences could be detected in either total fiber length or fiber diameter in the lungs with mild emphysema compared to normal lungs of the same age.
通过形态测量法测定了人肺实质中弹性纤维的长度和纤维直径分布。对33例年龄在1至85岁男性的肺进行了研究，其中包括9例轻度肺气肿患者的肺。这些研究表明，弹性纤维的总长度在生命早期就已存在，可能在10岁时就已形成，此后保持不变。平均纤维直径在婴儿期到成年期之间增加，但在生命的第三个十年之后可能不再进一步变化。与同年龄的正常肺相比，轻度肺气肿患者的肺在纤维总长度或纤维直径方面均未检测到显著差异。
