类风湿关节炎及其亚组中的HLA - DPA1和HLA - DPB1

HLA-DPA1 and HLA-DPB1 in rheumatoid arthritis and its subsets.

作者信息

Hutchings C J, Hillarby M C, McMahon M J, Ollier W E, Grennan D M

机构信息

University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford.

出版信息

Dis Markers. 1993 Jun;11(1):37-44. doi: 10.1155/1993/583825.

DOI:10.1155/1993/583825

PMID:8358964

Abstract

The aim of this study was to examine the relationship between HLA-DP and susceptibility to articular and extra-articular features (Felty's syndrome and vasculitis) of rheumatoid arthritis (RA). The possible association of DP types with severity of articular disease was also analysed. No statistically significant associations were observed between HLA-DP alleles and articular or extra-articular features of RA, or to the severity of the arthritis when p was corrected for the number of alleles tested.

摘要

本研究旨在探讨人类白细胞抗原-DP（HLA-DP）与类风湿关节炎（RA）关节及关节外表现（费尔蒂综合征和血管炎）易感性之间的关系。同时分析了DP类型与关节疾病严重程度的可能关联。在对检测的等位基因数量进行校正后，未观察到HLA-DP等位基因与RA的关节或关节外表现或关节炎严重程度之间存在统计学显著关联。