McKay D M, Perdue M H
Department of Pathology, Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada.
Dig Dis Sci. 1993 Sep;38(9):1735-45. doi: 10.1007/BF01303185.
Substantial amounts of data have been reported showing a role for immunomodulation of epithelial function (particularly ion secretion and permeability) using animal models of anaphylactic reactions. In part one of this review we outlined the main immune cell types and mediators/cytokines that are currently known to influence epithelial physiology either directly, or indirectly via an intermediate cell type. Here we will expand on the significance of these studies and show how antigenic activation of the mucosal immune system can evoke changes in epithelial function that may be beneficial to the host by mediating loss/inactivation of the antigen. However, a continued and inappropriate immune stimulation can lead to pathophysiological reactions and disease. Thus, we will present data on immune regulation of epithelial function with direct applicability to understanding the mechanism underlying human intestinal inflammatory and secretory disease. Finally, we highlight key strategic points in the cascade of immune events that can control epithelial function and thus may be of relevance in the formulation of new therapeutic approaches to intestinal inflammation.
已有大量数据报道，在过敏性反应动物模型中，免疫调节对上皮功能（特别是离子分泌和通透性）具有作用。在本综述的第一部分，我们概述了目前已知的主要免疫细胞类型以及直接或通过中间细胞类型间接影响上皮生理功能的介质/细胞因子。在此，我们将详述这些研究的重要性，并展示黏膜免疫系统的抗原激活如何通过介导抗原的丢失/失活引起上皮功能变化，而这种变化可能对宿主有益。然而，持续且不适当的免疫刺激会导致病理生理反应和疾病。因此，我们将呈现关于上皮功能免疫调节的数据，这些数据对于理解人类肠道炎症和分泌性疾病的潜在机制具有直接适用性。最后，我们强调了免疫事件级联反应中的关键战略要点，这些要点可控制上皮功能，因此可能与制定新的肠道炎症治疗方法相关。
