McKay D M, Perdue M H
Department of Pathology, Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada.
Dig Dis Sci. 1993 Aug;38(8):1377-87. doi: 10.1007/BF01308592.
During the last decade the traditional view of epithelial function being controlled solely by the endocrine and nervous systems has been expanded by the realization that immune cells also have an important part to play in the control of intestinal physiology. Here, we review the current immunophysiological data pertaining to the control of the function of the intestinal epithelium, with particular reference to ion secretion. The role of immunocompetent cells (lymphocytes, mast cells, and granulated phagocytes) and their chemical messenger molecules (ie, biogenic amines, eicosanoids, cytokines) is discussed and the general theme of cell cooperation and integration is emphasized.
在过去十年中，上皮功能仅由内分泌和神经系统控制的传统观点得到了扩展，因为人们认识到免疫细胞在肠道生理控制中也发挥着重要作用。在此，我们回顾了当前与肠道上皮功能控制相关的免疫生理学数据，尤其涉及离子分泌。讨论了免疫活性细胞（淋巴细胞、肥大细胞和颗粒吞噬细胞）及其化学信使分子（即生物胺、类花生酸、细胞因子）的作用，并强调了细胞合作与整合的总体主题。
