Guzzo M, Grandi C, Licitra L, Podrecca S, Cascinelli N, Molinari R
Division of Head and Neck Surgery, Istituto Nazionale Tumori, Milan, Italy.
Eur J Surg Oncol. 1993 Aug;19(4):316-9.
A series of 48 cases of malignant mucosal melanomas treated at the Milan Cancer Institute from 1975 to 1990 is retrospectively reviewed. There were 34 males and 14 females, and their ages ranged from 21 to 79 years (mean, 58). The site of origin of the tumor was the nasal cavity in 26 cases, the oral cavity in 15, larynx in two, lip mucosa in two, pharynx in two and upper esophagus in one. At presentation, the neoplasm was limited to the primary site in 60.4% of the patients. Most patients (34) were treated with surgery alone. Nine were treated with surgery combined with chemo- and/or radiotherapy and five with radiotherapy combined with chemotherapy and/or immunotherapy. Only when surgery was part of the treatment (42 of 48 cases) the patients were rendered disease free, but no further relapse of disease was documented in only five of these patients. The observed 2- and 5-year survival rate of the entire group was 45% and 21%, respectively. The 4-year disease-free survival rate was 7%. The median interval between therapy and the first relapse was 8.5 months (range, 1-66). In 44% of the patients the first recurrence of the tumor was at the primary site.
回顾性分析了1975年至1990年在米兰癌症研究所接受治疗的48例恶性黏膜黑色素瘤患者的病例资料。其中男性34例，女性14例，年龄在21岁至79岁之间（平均58岁）。肿瘤原发部位为鼻腔26例，口腔15例，喉2例，唇黏膜2例，咽2例，食管上段1例。初诊时，60.4%的患者肿瘤局限于原发部位。大多数患者（34例）仅接受了手术治疗。9例接受了手术联合化疗和/或放疗，5例接受了放疗联合化疗和/或免疫治疗。只有当手术作为治疗的一部分时（48例中的42例），患者才实现无病状态，但其中只有5例患者未记录到疾病进一步复发。整个组观察到的2年和5年生存率分别为45%和21%。4年无病生存率为7%。治疗与首次复发之间的中位间隔为8.5个月（范围1至66个月）。44%的患者肿瘤首次复发在原发部位。
