Penninks A H
TNO Toxicology and Nutrition Institute, Zeist, The Netherlands.
Food Addit Contam. 1993 May-Jun;10(3):351-61. doi: 10.1080/02652039309374157.
In this report the evaluation of a safety factor is assessed, according to the decision tree suggested by Renwick (1991a,b), to determine a Tolerable Daily Intake (TDI) value for the environmental contaminant bis(tri-n-butyltin)oxide (TBTO). Based on available literature the nature of the most sensitive parameter of TBTO-toxicity was perceived to be on lymphoid organs and lymphoid function. Subsequently, safety factors were derived in relation to published data on inter-species and inter-individual differences in both kinetics and dynamics of TBTO. Lack of information on human data concerning the nature of toxicity as well as kinetics and dynamics of TBTO finally resulted in a safety factor of 100. A TDI of 5 or 0.25 mg/kg bw per day was assessed based on reductions of lymphoid organ weights (thymus) or lymphoid function (resistance to T. spiralis), respectively. In addition, based on available data in rodents on kinetics and dynamics of TBTO, it is suggested that a combined TDI value for both tri- and dibutyltin compounds might have to be considered.
在本报告中，根据Renwick（1991a，b）建议的决策树，对安全系数进行了评估，以确定环境污染物双（三正丁基锡）氧化物（TBTO）的每日耐受摄入量（TDI）值。根据现有文献，TBTO毒性最敏感参数的性质被认为与淋巴器官和淋巴功能有关。随后，根据已发表的关于TBTO动力学和动态的种间和个体间差异的数据得出安全系数。由于缺乏关于TBTO毒性性质以及动力学和动态的人类数据，最终得出安全系数为100。分别根据淋巴器官重量（胸腺）的减少或淋巴功能（对旋毛虫的抵抗力）评估出TDI为每天5或0.25mg/kg体重。此外，根据啮齿动物中TBTO动力学和动态的现有数据，建议可能必须考虑三丁基锡化合物和二丁基锡化合物的综合TDI值。
