[Microstructure of placenta and activity of some respiratory enzymes --in pregnancy with treated and untreated fetal intrauterine hypotrophy syndrome].

The cases of fetal intrauterine hypotrophy syndrome were subjected to rest, dietetic and pharmacological treatment which included intravenous infusions of low molecular Dekstrane, intramuscular injections of Synacthen-Depot, Sadamine and Partusisten. The clear improvement of selected parameters of placenta efficiency during the management was observed. It included: mean increase of blood serum oxytocinase activity about 2.1 U, mean increase of quantity of estrogens excreted in 24-hour urine about 4.1 mg/24 hours, mean decrease of term-stabile alkaline phosphatase activity in blood serum about 16 U. The comparison of the state of hypotrophic newborns found in the group with hypotrophy treated during the course of pregnancy with the group of untreated hypotrophy permits to conclude: statistically significant more rarefied occurrence of newborns of low values according to Apgar scale, hypoglycemia, acidosis, anemia as well as respiratory distress syndrome and five-fold diminished perinatal mortality. It was demonstrated a clear correlation between many parameters of structure and activity of oxygenizing enzymes of placentae existed between the group with treated and untreated hypotrophy.