Gupta G, Srivastava A, Setty B S
Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
Indian J Exp Biol. 1993 Apr;31(4):305-11.
The androgenic regulation of the eleven enzymes of glycolytic pathway and two key enzymes of HMP pathway was studied in the initial segment, caput, corpus and cauda regions of the epididymis and in the vas deferens of rhesus monkey. The specific activities of enzymes were expressed as units of activity per mg DNA. Results in control animals indicate a marked difference in energy metabolism of epididymis and vas deferens. However, the epididymal duct itself did not show much regional variation in enzyme activities along its length. All the enzymes of the two pathways studied showed significant reduction after castration, the regulatory enzymes being affected more severely. On treatment with exogenous dihydrotestosterone, most of these enzymes showed stimulation in castrated monkeys, but none of them could be restored to normal level. The stimulation of these enzymes on treatment with exogenous dihydrotestosterone varied along the epididymal duct itself being maximum in the initial segment and minimum in the cauda region. The changes in the vas deferens were less marked as compared to the epididymis following castration and androgen replacement.
在恒河猴附睾的起始段、头部、体部和尾部区域以及输精管中，研究了糖酵解途径的11种酶和磷酸戊糖途径的2种关键酶的雄激素调节。酶的比活性以每毫克DNA的活性单位表示。对照动物的结果表明，附睾和输精管的能量代谢存在显著差异。然而，附睾管本身沿其长度在酶活性方面没有表现出太多区域差异。阉割后，所研究的两条途径的所有酶都显示出显著降低，调节酶受到的影响更严重。用外源性二氢睾酮治疗后，大多数这些酶在去势猴子中显示出刺激作用，但没有一种能恢复到正常水平。用外源性二氢睾酮治疗时，这些酶的刺激作用沿附睾管本身有所不同，在起始段最大，在尾部区域最小。与附睾相比，阉割和雄激素替代后输精管的变化不太明显。
