成纤维细胞刺激因子1，一种在血吸虫卵肉芽肿中产生的新型淋巴因子，可在体外刺激肝脏贮脂细胞。
Fibroblast-stimulating factor 1, a novel lymphokine produced in schistosomal egg granulomas, stimulates liver fat-storing cells in vitro.
作者信息
Greenwel P, Wyler D J, Rojkind M, Prakash S
机构信息
Division of Geographic Medicine and Infectious Diseases, New England Medical Center, Boston, Massachusetts 02111.
出版信息
Infect Immun. 1993 Sep;61(9):3985-7. doi: 10.1128/iai.61.9.3985-3987.1993.
We report that the novel lymphokine fibroblast-stimulating factor 1, produced within hepatic schistosomal egg granulomas, stimulates liver fat-storing cells (FSC) in vitro to proliferate and express fibronectin genes. Because FSC are critical in hepatic fibrogenesis generally, we propose that in vivo stimulation of FSC by fibroblast-stimulating factor 1 may be an important step in schistosomal liver fibrosis.
我们报告称，在肝血吸虫卵肉芽肿内产生的新型淋巴因子成纤维细胞刺激因子1，在体外可刺激肝脂肪储存细胞（FSC）增殖并表达纤连蛋白基因。由于FSC通常在肝纤维化形成过程中起关键作用，我们提出，成纤维细胞刺激因子1在体内对FSC的刺激可能是血吸虫性肝纤维化的一个重要步骤。
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