维森他汀，一种新型的20元大环内酰胺类抗肿瘤抗生素。
Vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic.
作者信息
Shindo K, Kamishohara M, Odagawa A, Matsuoka M, Kawai H
机构信息
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
出版信息
J Antibiot (Tokyo). 1993 Jul;46(7):1076-81. doi: 10.7164/antibiotics.46.1076.
PMID:8360102
Abstract
A new antitumor antibiotic vicenistatin was isolated from the culture broth of Streptomyces sp. HC34. The structure of vicenistatin was elucidated by NMR spectral analysis. Vicenistatin exhibited antitumor activity against human colon carcinoma Co-3 in the xenograft model.
摘要
从链霉菌属HC34菌株的培养液中分离出一种新的抗肿瘤抗生素维斯他汀。通过核磁共振光谱分析确定了维斯他汀的结构。在异种移植模型中，维斯他汀对人结肠癌Co-3表现出抗肿瘤活性。
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