吉尔夫霉素，一种与CC - 1065相关的新型抗肿瘤抗生素。

Gilvusmycin, a new antitumor antibiotic related to CC-1065.

作者信息

Tokoro Y, Isoe T, Shindo K

机构信息

Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.

出版信息

J Antibiot (Tokyo). 1999 Mar;52(3):263-8. doi: 10.7164/antibiotics.52.263.

DOI:10.7164/antibiotics.52.263

PMID:10348041

Abstract

A new antitumor antibiotic gilvusmycin was isolated from the culture broth of Streptomyces sp. QM16. The structure of gilvusmycin was related to CC-1065 and determined by NMR spectral analysis. Gilvusmycin exhibited antitumor activity against murine leukemia P388 in vivo.

摘要

从链霉菌属菌株QM16的发酵液中分离出一种新的抗肿瘤抗生素吉尔维霉素。吉尔维霉素的结构与CC-1065相关，并通过核磁共振光谱分析确定。吉尔维霉素在体内对小鼠白血病P388表现出抗肿瘤活性。