Jiu J, Mizuba S, Hribar J
Appl Environ Microbiol. 1977 Jan;33(1):26-30. doi: 10.1128/aem.33.1.26-30.1977.
The microbial transformation of 8-chloro-10,11-dihydrodibenz(b,f)(1,4)oxazepine (compound I) was undertaken to obtain new derivatives. Compound I was transformed by Hormodendrum sp. (NRRL 8133) to 8-chloro-10,11-dihydrodibenz(b,f)(1,4)oxazepine-11-one (compound II) and 2-(2-amino-4-chlorophenoxy)benzyl alcohol (compound IV). Microbial cleavage of the nonaromatic ring to form compound IV was accomplished by several other fungi. Compound I was transformed to 8-chlorodibenz(b,f)(1,4)oxazepine (compound III) by Hormodendrum cladosporioides (NRRL 8132).
对8-氯-10,11-二氢二苯并(b,f)(1,4)恶嗪（化合物I）进行微生物转化以获得新的衍生物。化合物I被链格孢属真菌（NRRL 8133）转化为8-氯-10,11-二氢二苯并(b,f)(1,4)恶嗪-11-酮（化合物II）和2-(2-氨基-4-氯苯氧基)苄醇（化合物IV）。非芳环的微生物裂解形成化合物IV是由其他几种真菌完成的。化合物I被枝孢状枝孢菌（NRRL 8132）转化为8-氯二苯并(b,f)(1,4)恶嗪（化合物III）。
