Sanders V, Conrad A J, Tourtellotte W W
Brain Research Institute, UCLA.
J Neuroimmunol. 1993 Jul;46(1-2):207-16. doi: 10.1016/0165-5728(93)90251-s.
Plaque classification is proposed based on observation of 348 plaques from 52 post-mortem multiple sclerosis (MS) cases. Four plaque types, ranging from 'earliest lesion' to 'inactive', are described according to immunological activation and degree of demyelination, seen by expression of the Major Histocompatibility Complex (MHC) Class II molecule, HLA-DR, and by Oil Red O staining, respectively. 40% of the plaques were inactive. This result highlights the need for a description of plaque activity for studies of the etiopathogenesis of MS; that is, the earliest and/or the most active plaques should contain the causative agent whereas the burnt out plaques should not.
基于对52例多发性硬化症（MS）尸检病例中348个斑块的观察，提出了斑块分类方法。根据主要组织相容性复合体（MHC）II类分子HLA-DR的表达以及油红O染色分别观察到的免疫激活和脱髓鞘程度，描述了从“最早病变”到“无活性”的四种斑块类型。40%的斑块无活性。这一结果凸显了在MS病因发病机制研究中描述斑块活性的必要性；也就是说，最早和/或最活跃的斑块应含有病原体，而陈旧性斑块则不应含有。
