活化的细胞毒性T淋巴细胞向中枢神经系统的迁移：转基因模型的应用
Trafficking of activated cytotoxic T lymphocytes into the central nervous system: use of a transgenic model.
作者信息
Oldstone M B, Southern P J
机构信息
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.
出版信息
J Neuroimmunol. 1993 Jul;46(1-2):25-31. doi: 10.1016/0165-5728(93)90230-v.
Abstract
We have used cell or tissue-specific promoters to express lymphocytic choriomeningitis virus (LCMV) proteins in selected cells in independent lines of transgenic mice. Upon adoptive transfers into these mice, MHC-restricted LCMV-specific cytotoxic T lymphocytes homed specifically to either the choroid plexus (SV40 promoter) or beta cells of the islets of Langerhans (rat insulin promoter). The availability of promoters specific for neurons, oligodendrocytes and astrocytes makes this approach compelling for evaluating T cell trafficking into the CNS and for analyzing antigen presentation in vivo in the CNS.
摘要
我们利用细胞或组织特异性启动子，在转基因小鼠独立品系的特定细胞中表达淋巴细胞性脉络丛脑膜炎病毒（LCMV）蛋白。将这些小鼠进行过继转移后，受主要组织相容性复合体（MHC）限制的LCMV特异性细胞毒性T淋巴细胞会特异性归巢至脉络丛（SV40启动子）或胰岛的β细胞（大鼠胰岛素启动子）。神经元、少突胶质细胞和星形胶质细胞特异性启动子的可用性，使得这种方法对于评估T细胞向中枢神经系统（CNS）的迁移以及分析CNS内的体内抗原呈递具有吸引力。
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