印度急性散发性非甲非乙型病毒性肝炎的病因学

Aetiology of acute sporadic non-A, non-B viral hepatitis in India.

作者信息

Arankalle V A, Chobe L P, Jha J, Chadha M S, Banerjee K, Favorov M O, Kalinina T, Fields H

机构信息

National Institute of Virology, Pune India.

出版信息

J Med Virol. 1993 Jun;40(2):121-5. doi: 10.1002/jmv.1890400208.

DOI:10.1002/jmv.1890400208

PMID:8360633

Abstract

Non-A, non-B (NANB) hepatitis viruses are now classified as hepatitis E (enterically transmitted) and hepatitis C (parenterally transmitted). India experiences a large number of epidemics of the enteric disease every year. In addition, about 70% of the sporadic cases among adults are also due to NANB hepatitis. With the availability of an immunoblot assay for the detection of anti-HEV-IgM and the polymerase chain reaction (PCR) for the detection of HCV-RNA, serum samples from epidemic and sporadic NANB patients were screened for these markers. We found that a large number of cases from the epidemics were HEV, though a few remained undiagnosed, while of the sporadic cases only a few could be diagnosed as HCV or HEV; a large proportion remained undiagnosed.

摘要

非甲非乙型（NANB）肝炎病毒现被归类为戊型肝炎病毒（经肠道传播）和丙型肝炎病毒（经肠道外传播）。印度每年都会出现大量此类肠道疾病的流行病例。此外，成人中约70%的散发病例也归因于NANB肝炎。随着用于检测抗戊型肝炎病毒免疫球蛋白M（anti-HEV-IgM）的免疫印迹试验以及用于检测丙型肝炎病毒核糖核酸（HCV-RNA）的聚合酶链反应（PCR）的出现，对流行病例和散发NANB患者的血清样本进行了这些标志物的筛查。我们发现，大量流行病例为戊型肝炎病毒感染，尽管仍有少数病例未得到诊断；而在散发病例中，仅有少数可诊断为丙型肝炎病毒或戊型肝炎病毒感染，大部分病例仍未得到诊断。