Newcombe J, Cuzner M L
Multiple Sclerosis Society Laboratory, Institute of Neurology, London, U.K.
J Neural Transm Suppl. 1993;39:155-63.
The Multiple Sclerosis Society Tissue Bank contains post-mortem central nervous system tissue from over 100 clinically and neuropathologically well-documented multiple sclerosis (MS) cases, and from normal control subjects. This bank is a resource centre which provides histologically screened snap-frozen material for immunological, neurochemical and nucleic acid studies in our own and other MS laboratories in Europe and the USA. In addition to immunopathological studies, Tissue Bank material has been used to investigate changes in CNS-specific proteins and lipids in MS plaques and responses of oligodendrocytes and astrocytes to the inflammatory demyelinating process. MS lesions detected in unfixed post-mortem brain and spinal cord by magnetic resonance imaging techniques prior to dissection have been characterized histologically and biochemically. A computer database on Tissue Bank post-mortem cases has been established to link clinical, pathological and scientific aspects of MS research.
多发性硬化症协会组织库包含来自100多例临床和神经病理学记录完善的多发性硬化症（MS）病例以及正常对照受试者的死后中枢神经系统组织。该库是一个资源中心，为欧洲和美国我们自己及其他MS实验室的免疫、神经化学和核酸研究提供经组织学筛选的速冻材料。除免疫病理学研究外，组织库的材料还用于研究MS斑块中中枢神经系统特异性蛋白质和脂质的变化以及少突胶质细胞和星形胶质细胞对炎性脱髓鞘过程的反应。在解剖前通过磁共振成像技术在未固定的死后脑和脊髓中检测到的MS病变已进行了组织学和生物化学特征分析。已建立了一个关于组织库死后病例的计算机数据库，以关联MS研究的临床、病理和科学方面。
