Eymin C, Jordan D, Saint-Pierre G, Kopp N
Laboratoire d'Anatomie Pathologique, Faculté de Médecine Alexis Carrel, Lyon, France.
J Neural Transm Suppl. 1993;39:127-34.
The aim of a human brain bank is to establish groups of matched brains (normal control versus pathological groups) for studying human diseases of the nervous system. This bank is obtained by means of autopsy performed with a very short post-mortem delay and from clinically and neuropathologically well-documented patients. According to research protocols, two types of brain tissue storage are performed: fixed tissue or frozen tissue. Brain dissection procedures are performed according to precise anatomical boundaries of each brain region. This paper will center on the questions raised by brain banking in relation to histological and immunocytochemical studies and to biochemistry and autoradiography of binding sites. The lack of neuroanatomical data of the human brain leads us to compare anatomical results obtained in animals to that of the human. Moreover, it is clear that human brains present numerous interindividual differences (Kopp et al., 1977; Jack et al., 1989). Therefore, investigations of the human brain should be made on a large series of brains indicating the necessity of a well-documented brain bank of tissue from normal controls and patients.
人脑库的目的是建立匹配的脑组（正常对照组与病理组），用于研究人类神经系统疾病。该脑库是通过尸检获得的，尸检在死后极短时间内进行，且取材于临床和神经病理学记录完备的患者。根据研究方案，进行两种类型的脑组织储存：固定组织或冷冻组织。脑解剖程序按照每个脑区精确的解剖边界进行。本文将围绕人脑库在组织学和免疫细胞化学研究、结合位点的生物化学及放射自显影方面所引发的问题展开。人类大脑缺乏神经解剖学数据，这使我们将在动物身上获得的解剖结果与人类的进行比较。此外，很明显人类大脑存在众多个体差异（科普等人，1977年；杰克等人，1989年）。因此，对人类大脑的研究应该在大量的脑样本上进行，这表明需要一个记录完备的来自正常对照组和患者的脑组织库。
