Alafuzoff I, Winblad B
Department of Pathology, Huddinge University Hospital, Sweden.
J Neural Transm Suppl. 1993;39:235-43.
Brain banks for neurological diseases serve as a link between the clinician, the neuropathologist and the basic scientist who require brain tissue samples from patients who have undergone a thorough clinical investigation and whose brains have been subjected to detailed neuropathological analysis. In order to provide research groups with post-mortem brain tissue from patients who show clinical signs of dementia such as Alzheimer's disease (AD), senile dementia of Alzheimer type (SDAT), vascular dementia including multi-infarct dementia (MID) and mixed dementia, a brain bank was established at Huddinge University Hospital at the end of 1988. The brain bank provides either rapidly or slowly frozen tissue samples, tissue samples fixed in formalin (short/long fixation time), cerebrospinal fluid (CSF), and blood samples. Average postmortem times are from 3-47 hours. The information available on the cases includes the clinical diagnosis, the premortem clinical investigation with behavioral observations, psychometric and neuropsychological test data, premortem medication, cause of death, agonal state, pH in brain and CSF, and the general anatomic and neuropathologic assessments leading to the final diagnosis.
神经疾病脑库是临床医生、神经病理学家和基础科学家之间的纽带，这些人员需要从经过全面临床调查且大脑已接受详细神经病理学分析的患者身上获取脑组织样本。为了向研究团队提供患有痴呆临床症状患者的尸检脑组织，如阿尔茨海默病（AD）、阿尔茨海默型老年痴呆（SDAT）、包括多发性梗死性痴呆（MID）在内的血管性痴呆以及混合性痴呆，1988年底在胡丁厄大学医院设立了一个脑库。该脑库提供快速或慢速冷冻的组织样本、用福尔马林固定的组织样本（固定时间短/长）、脑脊液（CSF）和血液样本。平均死后时间为3至47小时。病例的可用信息包括临床诊断、生前临床调查（包括行为观察、心理测量和神经心理学测试数据）、生前用药、死亡原因、濒死状态、脑和脑脊液中的pH值，以及导致最终诊断的大体解剖和神经病理学评估。
