Meyers C A, Yung W K
Department of Neuro-Oncology, University of Texas, Anderson Cancer Center, Houston.
J Neurooncol. 1993 Mar;15(3):265-7. doi: 10.1007/BF01050073.
A case is reported of a 40 year old woman treated with intraventricular IL-2 for leptomeningeal disease who developed progressive cognitive dysfunction. This deterioration started 3 months post-treatment and worsened over the ensuing 4 years. MRI revealed white matter abnormalities that were not present on the pretreatment scan. Although free of disease, the patient has a subcortical dementia and is unable to work. The potential for progressive brain injury and subsequent disability related to intraventricular IL-2 therapy is discussed.
报告了一例40岁女性，因柔脑膜疾病接受脑室内白细胞介素-2治疗，出现进行性认知功能障碍。这种恶化在治疗后3个月开始，并在随后4年中加重。磁共振成像显示出治疗前扫描未出现的白质异常。尽管疾病已痊愈，但该患者患有皮质下痴呆，无法工作。文中讨论了与脑室内白细胞介素-2治疗相关的进行性脑损伤及后续残疾的可能性。
