de Waal R, Algra P R, Heimans J J, Wolbers J G, Scheltens P
Department of Neurology, Free University Hospital, Amsterdam, The Netherlands.
J Neurooncol. 1993 Mar;15(3):269-73. doi: 10.1007/BF01050074.
A 63-year old woman with breast carcinoma developed leucoencephalopathy and local brain necrosis after intraparenchymal infusion of methotrexate. This iatrogenic condition was caused by drain disconnection of the Ommaya device (bore hole type). The diagnosis of this rare complication of an Ommaya device was based on multiplanar MR-imaging. The case is discussed with regard to the complications of intraventricular chemotherapy by means of an Ommaya reservoir.
