Wepler R, Burkhardt H, Rommel K
Arch Dermatol Res (1975). 1977 Jan 31;257(3):287-92. doi: 10.1007/BF00741845.
Specific pathogen free guinea pigs were treated with varying dosis of fluocortolone for 15 days. The treated animals showed the same per cent weight gain as the controls. The total hydroxyproline content of the skin and the hydroxyproline content in different collagen fractions was the same in treated and untreated animals. Thus fluocortolone seems to have no specific effect on the synthesis or the breakdown of collagen in the guinea pig skin. Also the physical development of the animals, kept under defined conditions, failed to show a catabolic effect of of fluorcortolone.
将无特定病原体的豚鼠用不同剂量的氟可的索处理15天。经处理的动物体重增加百分比与对照组相同。处理组和未处理组动物皮肤的总羟脯氨酸含量以及不同胶原蛋白组分中的羟脯氨酸含量相同。因此，氟可的索似乎对豚鼠皮肤中胶原蛋白的合成或分解没有特定影响。同样，在特定条件下饲养的动物的身体发育也未显示出氟可的索的分解代谢作用。
