Lindboe W G, Hayakawa K
Block Drug Company, Inc., Jersey City, New Jersey.
J Parenter Sci Technol. 1993 May-Jun;47(3):138-41.
Thermal processing of product in its final container to achieve product safety has been a major process operation of the pharmaceutical and food industries for many years. The original batch type autoclave (retort) is still in prevalent use today. However, high volume continuous and semi-continuous methods are also utilized, primarily in the food industry. Each different terminal sterilization method and load type requires assurance of process adequacy. This paper examines some of the types of moist heat terminal sterilizers in both the pharmaceutical and food industries and compares their features.
在最终容器中对产品进行热处理以确保产品安全，多年来一直是制药和食品行业的主要工艺操作。原始的间歇式高压灭菌器（杀菌釜）至今仍在广泛使用。然而，高产量的连续和半连续方法也被采用，主要用于食品行业。每种不同的终端灭菌方法和负载类型都需要确保工艺的充分性。本文研究了制药和食品行业中一些湿热终端灭菌器的类型，并比较了它们的特点。
