Extraction and analysis by high-performance liquid chromatography of antibiotics in a drug delivery system for farmed fish.

Simple assays for extraction and determination of the concentrations of the antibiotics oxytetracycline, oxolinic acid, and flumequine in a drug dosage form for farmed fish are described. HPLC with UV detection was used in the analyses. The recovery of all three drugs was approximately 100%, and the precision varied from 0.5-3.0%. The methods are applicable to the production control, quality control, and stability control of the products.