Miyamura T, Obama K, Takahira H, Uike N, Kozuru M
Department of Hematology, National Kyushu Cancer Center Hospital.
Rinsho Ketsueki. 1993 Jul;34(7):882-4.
A 69-year-old male was admitted to our hospital complaining of skin pigmentation. Masses in bilateral adrenal glands were noted on computed tomography. An exploratory laparotomy revealed malignant lymphoma confined to the bilateral adrenal glands. Histological diagnosis was diffuse mixed-cell type, B-cell lymphoma. Laboratory tests disclosed an elevated ACTH level and decreased urinary 17KS and 170HCS secretion. Based on hypofunction of adrenal glands and skin pigmentation, the patient was diagnosed as having Addison's disease. After complete remission with combination chemotherapy, adrenal function recovered normal and pigmentation disappeared, Addison's disease is an extremely rare complication of primary malignant lymphoma of the adrenal gland.
一名69岁男性因皮肤色素沉着入住我院。计算机断层扫描发现双侧肾上腺有肿块。剖腹探查显示恶性淋巴瘤局限于双侧肾上腺。组织学诊断为弥漫性混合细胞型B细胞淋巴瘤。实验室检查发现促肾上腺皮质激素（ACTH）水平升高，尿17酮类固醇（17KS）和17羟皮质类固醇（17OHCS）分泌减少。基于肾上腺功能减退和皮肤色素沉着，该患者被诊断为艾迪生病。联合化疗完全缓解后，肾上腺功能恢复正常，色素沉着消失，艾迪生病是肾上腺原发性恶性淋巴瘤极其罕见的并发症。
