Mantzios George, Tsirigotis Panagiotis, Veliou Filio, Boutsikakis Iosif, Petraki Lillian, Kolovos John, Papageorgiou Sotirios, Robos Yannis
Hematology Department, Metropolitan Hospital, Ethn. Makariou-9 & El. Venizelou-1, Neo-Faliro, 18547 Piraeus, Greece.
Ann Hematol. 2004 Jul;83(7):460-3. doi: 10.1007/s00277-003-0838-3. Epub 2004 Jan 17.
Primary adrenal lymphoma (PAL) is an extremely rare entity and adrenal insufficiency is a common complication. Bilateral enlargement of adrenal glands should raise the suspicion of lymphoma, especially in patients with clinical or laboratory features of adrenal insufficiency. Most of these cases are highly aggressive tumors and should be treated with multiagent chemotherapy. The role of bilateral adrenalectomy and/or radiotherapy cannot be estimated. Our patient with PAL was an 80-year-old man who presented with clinical and laboratory features of adrenal insufficiency. Combination chemotherapy plus rituximab was unsuccessful and our patient died from progressive disease.
原发性肾上腺淋巴瘤（PAL）是一种极其罕见的疾病，肾上腺功能不全是常见的并发症。双侧肾上腺肿大应引起对淋巴瘤的怀疑，尤其是在有肾上腺功能不全临床或实验室特征的患者中。这些病例大多是高度侵袭性肿瘤，应采用多药联合化疗。双侧肾上腺切除术和/或放疗的作用尚无法评估。我们的PAL患者是一名80岁男性，表现出肾上腺功能不全的临床和实验室特征。联合化疗加利妥昔单抗治疗失败，患者死于疾病进展。
