Masu Y, Wolf E, Holtmann B, Sendtner M, Brem G, Thoenen H
Abteilung Neurochemie, Max-Planck-Institut für Psychiatrie, Martinsried, Germany.
Nature. 1993 Sep 2;365(6441):27-32. doi: 10.1038/365027a0.
CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a subpopulation of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determined motor neuron degeneration, its physiological function remained elusive. Here it is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength.
睫状神经营养因子（CNTF）是一种在出生后由有髓施万细胞和一部分星形胶质细胞表达的胞质分子。尽管给予CNTF可预防损伤介导的和基因决定的运动神经元变性，但其生理功能仍不清楚。本文报道，通过同源重组消除CNTF基因表达会导致成年小鼠运动神经元进行性萎缩和丧失，这在功能上表现为肌肉力量虽小但显著降低。
