Morrison L D, Bergeron C, Kish S J
Human Neurochemical Pathology Laboratory, Clarke Institute Of Psychiatry, Toronto, Ont., Canada.
Neurosci Lett. 1993 May 14;154(1-2):141-4. doi: 10.1016/0304-3940(93)90191-m.
We measured the activity of S-adenosylmethionine decarboxylase (SAMDC), a key regulatory enzyme of polyamine biosynthesis, in autopsied brain from 13 patients with Alzheimer's Disease (AD). As compared with the controls, mean enzyme activity was increased by 37-96% in all seven examined brain regions with statistically significant increases in temporal cortex (+96%), frontal cortex (+69%) and hippocampus (+90%). The elevated SAMDC may have occurred as part of a generalized polyamine response to brain injury, which has been previously described in experimental animal conditions. Above-normal SAMDC activity implies increased levels/metabolism of spermidine and spermine, two polyamines which are involved in neuronal regeneration, growth factor production, and activation of excitatory N-methyl-D-aspartate preferring glutamate receptors. Our data suggest the involvement of the polyamine system in the brain reparative and/or pathogenetic mechanisms of AD.
我们检测了13例阿尔茨海默病（AD）患者尸检大脑中多胺生物合成的关键调节酶S-腺苷甲硫氨酸脱羧酶（SAMDC）的活性。与对照组相比，在所有七个检测的脑区中，平均酶活性增加了37%-96%，其中颞叶皮质（+96%）、额叶皮质（+69%）和海马体（+90%）有统计学显著增加。SAMDC升高可能是对脑损伤的全身性多胺反应的一部分，这在实验动物条件下已有描述。SAMDC活性高于正常意味着亚精胺和精胺水平/代谢增加，这两种多胺参与神经元再生、生长因子产生以及兴奋性N-甲基-D-天冬氨酸偏好性谷氨酸受体的激活。我们的数据表明多胺系统参与了AD的脑修复和/或发病机制。
